заболевание рак

Virus fiber Е7 is capable to break regulation of the control клеточого a cycle, forming a stable inactive complex with a series of fibers regulating a cellular cycle; stimulates succession of events in a S-phase of a cellular cycle by инициации репликации virus genes and infringement of regulation пролиферации the transformed cells{cages}. The opportunity of uncontrollable synthesis cellular ДНК under influence of fiber Е7 is supposed. Thus, fiber Е7 is multifunctional due to interaction with cellular fibers; fiber Е7 is capable to cancel a stop of cells{cages} in a G1-phase of a cellular cycle, to render митогенное influence and to stimulate uncontrollable synthesis ДНК [12,13,16,22]. Подробнее...

There are messages on detection virus ДНК in cells{cages} РШМ both in integrated, and in эписомальной forms. Essential distinctions in character of integration ВПЧ of types 16 and 18 come to light. On the basis of the data on forms of integration virus ДНК assumptions of the possible{probable} importance of both forms персистенции ДНК ВПЧ types 16 and 18 are stated, and integration is not a determining part in the mechanism of an induction туморогенеза [23]. Подробнее...