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Онкогенный the potential папилломавирусов essentially varies; on ability to initiate диспластические (precancer) changes and a cancer папилломавирусы are conditionally divided{shared} into groups of "high" and "low" risk of occurrence of tumoral transformation infected эпителия. Types ВПЧ 6,11, 42, 43, 44 have been classified as types of low risk of development of a cancer, types 16, 18, 48, 56 - high risk. So, ВПЧ types 6 and 11 are the reason peaked кондилом, are frequently identified at дисплазиях easy and average degrees of weight and are seldom connected to tumours шейки a uterus. ВПЧ types 16 and 18 prevail of other types папилломавирусов at РШМ, ВПЧ type 16 comes to light in 50-70 % of cases, in 10-20 % comes to light ВПЧ type 18, other types ВПЧ of high risk come to light much less often [13,14,21]. Most frequently meeting 16 type of a virus is determined, it{he} is revealed in 21 % of cases CIN-I, in 57 % of cases CIN-II-III. With an infection types of a virus 16 and 18 associate 67-93 % of cases РШМ, the virus of type 18 is found out approximately in 2 times less often than a virus of type 16 [11,13.15,18]. The virus of a papilloma of type 18 is associated with development аденокарцином, has higher онкогенный potential, with it{him} connect fast rate of a tumoral progression, a low level of a differentiation infected эпителия, the adverse forecast others онкогенными types [12,14]. Подробнее...

1491 patient with a cancer has taken part in research BCRIG01 dairy железы with positive axillary лимфоузлами; middle age has made 49 years, 62 % of patients had from 1 up to 3 лимфоузлов, at 69 % of a tumour were рецепторопозитивными on РЭ and РП, at 20 % - positive on HER2/neu. All patients having positive РЭ and РП, received also тамоксифен in a doze of 20 mg / ЯТФ. Within 5 years. The median of time of supervision at the moment of the analysis of results has made 33 (0-49) months. Подробнее...