рак полового члена
Depth инвазии tumours, defeat of lymphatic vessels and units, параметральная and влагалищная инфильтрация do not depend from молекулярно-genetic a determinant of infection ВПЧ [14]. Кing (1989) has not found out communication{connection} between type ВПЧ revealed in a tumour and frequency of metastasises in регионарные лимфоузлы, Girardi (1992) observed more often defeat параметриев and лимфоузлов in cases, positive on ВПЧ type 16. Results of researches Sebbelov (1991), Kentner (1993), Ikenberg (1994) have not shown association between молекулярно-genetic determinants of infection ВПЧ and the forecast, in works Walker (1989) and Burnett (1992) is informed on much worse forecast in cases, positive on ВПЧ type 18 [цит. On 14]. However the majority of researches includes no more than 100 cases, thus definition of presence of virus sequences was made by a method of блот-hybridization on Саузерну, allowing to reveal fragments генома ВПЧ no more than in 75 % of cases РШМ [14]. Подробнее...
The decision on a choice of preparations for chemotherapy of the second line should be based, first of all, on definition of sensitivity of a tumour to derivatives of platinum after chemotherapy of the first line. The interval between the termination{ending} of therapy of the first line and progressing of disease more than 6 months testifies to high sensitivity of a tumour derivatives of platinum. Such patient for treatment of relapses should be appointed a combination of derivatives of platinum and new preparations from among that are used for carrying out of the second line of chemotherapy. At separate patients with duration of remission more than 12 months probably carrying out of chemotherapy of the second line by the same combination which was used at a stage of an induction. Frequency of objective effect at use of a combination of derivatives of platinum (is $more often карбоплатина in view of his{its} smaller toxicity) and new preparations makes 30-50 % at average life expectancy of sick 12-14 months. Подробнее...
