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Modern молекулярно-trouble-shooting tests quickly move ahead in a direction of increase of their sensitivity and specificity. Now for identification virus ДНК various techniques of hybridization ДНК and molecular cloning are used. The most sensitive method now recognizes полимеразная chain reaction with типоспецифическими and species-specific праймерами, allowing to reveal virus sequences in геноме cells{cages} of tumours шейки a uterus in 95-100 % of cases [5,14,18,22]. Now it is identified more than 100 types ВПЧ, are in detail described more than 70 types, the fact is fixed, that certain types ВПЧ can infect strictly certain kind эпителия and to cause characteristic changes. Revealing of multi-variant approach of genotypes ВПЧ and identification of the data specific accumulation about malignant transformation генитальных кондилом have allowed to consider{examine} папилломавирус as possible{probable} этиологический the factor of development РШМ [13,15,20,23]. Подробнее...

Viruses of papillomas concern to family паповавирусов (Papovaviridae) and represent group of the viruses amazing large horned livestock, birds and the person which are capable to infect базальные cells{cages} of a leather{skin} and flat эпителия. Папилломавирусы - one of the most heterogeneous groups of viruses which criterion of a differentiation is the degree of genetic relationship of viruses according to molecular hybridization: she{it} can change from 10 up to 85 %. Diameter of virus particles of 55 nanometers. The virus has no external environment. Капсид a virus will consist from 72 капсомеров. The detailed analysis of molecule ДНК ВПЧ became possible{probable} after development of a technique of splitting ДНК with use эндонуклеаз and the analysis of these fragments with the help gel - электрофореза. The given method has allowed to define{determine} characteristic pictures of splitting ДНК and to create a physical card{map} of an arrangement of points of splitting in геноме various папилломавирусов [20]. Подробнее...