онкология полости рта

The first researches devoted эпидемиологии РШМ, have appeared in a century. Rigoni-Stern in 1842 has published the data based on studying of the register of death in Verona with 1760 on 1830. It{he} has noticed, that РШМ much more often caused death of married women and widows and did not meet at virgins and монахинь. This circumstance has allowed the scientist to state a hypothesis about infectious origin РШМ. Known interest submit data, published F.Gagnon (1950), - at studying 13000 case records монахинь Montreal and Quebec РШМ has not been found out never. The author connected similar results with low frequency of inflammatory diseases шейки a uterus at монахинь. In review Mogaji (1973) it is shown, that гистологически confirmed плоскоклеточный РШМ at virgins represents an exclusive rarity, these data are confirmed with researches Kessler (1976) and Skoqg (1982). Results of the epidemiological researches concerning a role in occurrence РШМ of the early beginning of a sexual life, early first pregnancy, often change of sexual partners, and also the infectious diseases transmitted in the sexual way are published. Подробнее...

The authentic establishment of association папилломавирусов with development генитальной неоплазии has allowed to approach closely to an opportunity to analyze complex{difficult} and questions at issue of correlation caused ВПЧ молекулярно-genetic changes with clinical features and forecast РШМ. Clinical current РШМ is influenced with histologic type and a degree of a differentiation of a tumour, the size of a primary tumour, depth инвазии subject fabrics and involving in tumoral process прилежащих to шейке a uterus of fabrics, лимфососудистого spaces and регионарных лимфоузлов. Forecast РШМ the big sizes of a primary tumour, a low degree of a differentiation of a tumour, presence of metastatic defeat регионарных лимфоузлов worsen, young age of patients [2,14]. Messages, соотносящие молекулярно-genetic determinants of the ВПЧ-INFECTION at РШМ with гистопатологическими both clinical features of tumours and forecast РШМ, contain inconsistent results. ВПЧ type 16 meets in высокодифференцированных плоскоклеточных tumours while ВПЧ type 18 it is associated with плоскоклеточными tumours of a low degree of a differentiation and аденокарциномами [13,14] is more often. Подробнее...