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Регуляторная the area virus генома (upstream regulatory region, URR) settles down between the end of area of late genes and the beginning of area of early genes. Open frameworks of reading ORF генома a virus are divided{shared} on early (early, Е) and late (late, L) sites. The early fragment includes genes Е1-Е7 coding synthesis of fibers, responsible{crucial} for various functions in process репликации a virus and transformation of cells{cages}. Genes Е1 and Е2 are responsible{crucial} for репликацию a virus, and also participate in regulation of a transcription virus генома. The product of gene Е1 is responsible for maintenance персистенции virus генома in эписомальной to the form. Gene Е2 codes products which can as a trance - activate, and to suppress экспрессию early genes and энхенсерных sites URR. Трансактивирующий the factor is identified in precancer changes шейки a uterus, репрессирующий the factor in vivo is not identified [16]. Gene Е4 participates during maturing virus particles, genes Е5-Е7 possess трансформирующим potential. Genes Е6 and Е7 are always defined{determined} and экспрессируются in tumours шейки a uterus and received of tumours шейки a uterus cellular lines. The biological effect трансформирующего potential of genes Е6 and Е7 will be considered below. The late fragment генома will consist of genes L1 and L2, coding structural fibers вириона [5,21]. Подробнее...

Slavin et al. informs on average percent{interest} локорегиональных relapses - 11,7 % at the average period of supervision 5,4 years in a series of 120 patients by which reconstruction with use of own fabrics has been executed at II and III stages of a cancer dairy железы. Thus basically relapses Would be observed at patients with III stage [11]. Подробнее...