детская онкология и гемотология

Thus, gene Е6 is multifunctional fiber, трансактивирующая which activity assumes participation in regulation of a transcription, interaction with a gene р53, his{its} degradation, in infringement of the mechanism of the control of cellular growth and process of a differentiation of cells{cages}. However till now there is no harmonous representation about the mechanism of interaction of virus fiber Е6 with cellular fibers in vivo. Virus fiber Е7 cooperates with cellular fiber Rb105, Rb-related fibers and Н1-киназой. These interactions are the independent processes necessary for effective transformation of cells{cages} by fiber. Fiber pRb (р105) is a product of a gene ретинобластомы, супрессора cellular growth. Подробнее...

During tumoral transformation the key role is played with virus genes Е6 and Е7 which activity is supervised регуляторным by site URR. This site генома contains area of the virus promotor, a locus репликации, энхенсерные elements, активирующие the sequences necessary for репликации virus ДНК, sites of linkage for fiber Е2, cellular factors of a transcription, receptors of a progesterone and глюкокортикоидных hormones [16]. In регуляторной areas генома the promotor р97 (ВПЧ type 16), р105 (ВПЧ type 18), regulating экспрессию virus genes settles down; activity of the promotor is adjusted by virus and cellular fibers. Онкобелок Е6 plays a role коактиватора, cooperating with factors of a transcription and elements of the basic транскрипционного a complex. Подробнее...