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In research AGO-GINECO authors have estimated expediency of addition антрациклинов to a combination карбоплатин паклитаксел. Inclusion эпирубицина has strengthened toxicity of a combination, but has not improved results of therapy [10]. In research SCOTROC comparison available today in our disposal таксанов is made: паклитаксела and доцетаксела [11]. Both preparations in a combination with карбоплатином have shown identical frequency of objective effects and time before progressing. The combination карбоплатин-паклитаксел possessed more expressed нейротоксичностью while карбоплатин-доцетаксел caused development нейтропении is more often. Подробнее...

Authors conclude that the percent{interest} of development of local relapses does not differ from the data рецидивирования the ambassador стандарной мастэктомии, however these data force to think of influence of local relapses on the general{common} survival rate at the given category of patients. In this connection the approach to treatment of relapses should be same, as well as at relapses after modified radical мастэктомии. Подробнее...