радиоизотопы онкология

The direction of action of fiber Е6 (супрессорное or трансактивирующее) is defined{determined} by character, position and number of sites of linkage транскрипционных factors in promotors. The promotor р97 (ВПЧ type 16) can play a role in maintenance of a latent condition of a virus infection. With онкобелком Е6 ВПЧ types 16 and 18 7 cellular fibers cooperate at least, now from them 3 cellular fibers are identified: р53, Е6-АР, Е6-ВР. The gene р53 is associated both with the control of cellular growth, and with неопластической transformation; делеции or mutations in some cases transform р53 in active онкоген. Not all malignant tumours have mutations р53, the alternative mechanism инактивации р53 however is proved by linkage with онкобелком Е6 ВПЧ types 16 and 18, that results in loss of the control for пролиферацией cells{cages}. Cellular fiber Е6-АР (Е6 associated protein) in a complex with онкобелком Е6 participates in degradation р53, and also, probably, shortens the period полужизни and reduces a level р53 in ВПЧ-иммортализованных cells{cages}. Fiber Е6-ВР (E6-binding protein) cooperates with gene Е6 ВПЧ of types 16 and 18, that in result results in inhibition of process of a differentiation of cells{cages} and, probably, creates conditions for репликации virus ДНК. Подробнее...

The concept of virus nature РШМ has a long history and is inextricably related with researches кондилом various localizations. Генитальные кондиломы are described even in works on antique medicine. The first assumptions of the infectious nature of a cancer шейки a uterus has stated in 1842 Rigoni-Stern. In 1903 Borrel and Bosc have offered the virus theory of development of tumours; Rous, Kidd (1938); Rous, Friedewald (1941) have received proofs of amplification{strengthening} of activity опухолеродных viruses at the presence of cancerogenic substances. Achievements in эксперементальной to virology have allowed L.A.Zilberu (1945), later Horsfall (1963) and Southam (1964) to formulate positions about опухолеродных viruses as the agents transforming a normal cell{cage} in tumoral by means of influence on its{her} genetic material, action of these agents differs from infectious, and in the further duplication of already arisen tumoral cells{cages} опухолеродные viruses of a role do not play. Подробнее...