онколог г москва

Depth инвазии tumours, defeat of lymphatic vessels and units, параметральная and влагалищная инфильтрация do not depend from молекулярно-genetic a determinant of infection ВПЧ [14]. Кing (1989) has not found out communication{connection} between type ВПЧ revealed in a tumour and frequency of metastasises in регионарные лимфоузлы, Girardi (1992) observed more often defeat параметриев and лимфоузлов in cases, positive on ВПЧ type 16. Results of researches Sebbelov (1991), Kentner (1993), Ikenberg (1994) have not shown association between молекулярно-genetic determinants of infection ВПЧ and the forecast, in works Walker (1989) and Burnett (1992) is informed on much worse forecast in cases, positive on ВПЧ type 18 [цит. On 14]. However the majority of researches includes no more than 100 cases, thus definition of presence of virus sequences was made by a method of блот-hybridization on Саузерну, allowing to reveal fragments генома ВПЧ no more than in 75 % of cases РШМ [14]. Подробнее...

Known types папилломавирусов the person are similar on the genetic structure. The genetic material of a virus is submitted by ring two-chained molecule ДНК in length about 8000 pairs the bases that corresponds{meets} to weight about D.Odna's 5 million from strings ДНК contains 9 open frameworks of reading (open reading frames, ORF) which potentially code up to 10 proteins, and регуляторный a site генома (upstream regulatory region, URR). Other string ДНК not coding. Подробнее...