консультации иммунолога онкология заболевания москва

The concept of virus nature РШМ has a long history and is inextricably related with researches кондилом various localizations. Генитальные кондиломы are described even in works on antique medicine. The first assumptions of the infectious nature of a cancer шейки a uterus has stated in 1842 Rigoni-Stern. In 1903 Borrel and Bosc have offered the virus theory of development of tumours; Rous, Kidd (1938); Rous, Friedewald (1941) have received proofs of amplification{strengthening} of activity опухолеродных viruses at the presence of cancerogenic substances. Achievements in эксперементальной to virology have allowed L.A.Zilberu (1945), later Horsfall (1963) and Southam (1964) to formulate positions about опухолеродных viruses as the agents transforming a normal cell{cage} in tumoral by means of influence on its{her} genetic material, action of these agents differs from infectious, and in the further duplication of already arisen tumoral cells{cages} опухолеродные viruses of a role do not play. Подробнее...

Process of integration is accompanied by partial loss of a genetic material of a virus, thus virus a gene irrespective of делеций loses ability to full репликации, and in the cells{cages} containing integrated cellular gene, there is no production of virus particles. Assume, that integration represents активационный the mechanism of a progression неоплазии from дисплазии a heavy degree to a cancer; she{it} originally carries поликлональный character. Most frequently in канцерогенез шейки a uterus are involved certain{determined} speed up chromosomes 5,6,10,11 and 17. Integration virus ДНК induces instability cellular генома and as consequence{investigation} an induction of infringements in the various chromosomes tested on loss of heterozygosity. The site of primary integration virus ДНК is not determined, quite often it{he} settles down near to cellular онкогенов [4]. Подробнее...