мнии онкологии

Thus, today in our disposal there is a lot of effective preparations and modes for treatment of patients by the widespread cancer яичников. As the first line of chemotherapy it is possible to use the combined modes (карбоплатин-паклитаксел, цисплатин-паклитаксел, карбоплатин-доцетаксел or CAP) or monotherapy by preparations of platinum (цисплатин 100 mg / m2 each 3 weeks of 6 rates or 50 mg / m2 weekly within 9 weeks, карбоплатин AUC x 5-7 each 3-4 weeks of 6 rates). The patients who have received at the first stage of treatment modes without inclusion таксанов, should receive necessarily таксаны in the second line of chemotherapy. At purpose{assignment} of the above-stated preparations and combinations in full dozes and recommended intervals it is possible to expect for reception of average time before progressing 15-17 months and average life expectancy of 30-36 months. Подробнее...

Originally in researches GOG 111 and OV-10 it has been shown, that паклитаксел in a combination with цисплатином essentially improve results of treatment in comparison with a combination цисплатин-циклофосфан. High нейротоксичность combinations цисплатин-паклитаксел has made actual replacement цисплатина on карбоплатин. In several researches [Neijt J.P., AGO, GOG-158] it has been shown, that such replacement does not result in deterioration of the remote results and essentially improves bearableness of treatment. Then in research GOG-132 it is revealed, that at purpose{assignment} as combinations паклитаксела and цисплатина, and consecutive use of two preparations (цисплатина for the first line and паклитаксела for the second line), life expectancy of patients is identical. Thus, necessity of use таксанов at various stages of treatment for achievement of the best results has been once again underlined. Подробнее...