врач онколог

Originally in researches GOG 111 and OV-10 it has been shown, that паклитаксел in a combination with цисплатином essentially improve results of treatment in comparison with a combination цисплатин-циклофосфан. High нейротоксичность combinations цисплатин-паклитаксел has made actual replacement цисплатина on карбоплатин. In several researches [Neijt J.P., AGO, GOG-158] it has been shown, that such replacement does not result in deterioration of the remote results and essentially improves bearableness of treatment. Then in research GOG-132 it is revealed, that at purpose{assignment} as combinations паклитаксела and цисплатина, and consecutive use of two preparations (цисплатина for the first line and паклитаксела for the second line), life expectancy of patients is identical. Thus, necessity of use таксанов at various stages of treatment for achievement of the best results has been once again underlined. Подробнее...

The direction of action of fiber Е6 (супрессорное or трансактивирующее) is defined{determined} by character, position and number of sites of linkage транскрипционных factors in promotors. The promotor р97 (ВПЧ type 16) can play a role in maintenance of a latent condition of a virus infection. With онкобелком Е6 ВПЧ types 16 and 18 7 cellular fibers cooperate at least, now from them 3 cellular fibers are identified: р53, Е6-АР, Е6-ВР. The gene р53 is associated both with the control of cellular growth, and with неопластической transformation; делеции or mutations in some cases transform р53 in active онкоген. Not all malignant tumours have mutations р53, the alternative mechanism инактивации р53 however is proved by linkage with онкобелком Е6 ВПЧ types 16 and 18, that results in loss of the control for пролиферацией cells{cages}. Cellular fiber Е6-АР (Е6 associated protein) in a complex with онкобелком Е6 participates in degradation р53, and also, probably, shortens the period полужизни and reduces a level р53 in ВПЧ-иммортализованных cells{cages}. Fiber Е6-ВР (E6-binding protein) cooperates with gene Е6 ВПЧ of types 16 and 18, that in result results in inhibition of process of a differentiation of cells{cages} and, probably, creates conditions for репликации virus ДНК. Подробнее...