моксотерапия и онкология

Регуляторная the area virus генома (upstream regulatory region, URR) settles down between the end of area of late genes and the beginning of area of early genes. Open frameworks of reading ORF генома a virus are divided{shared} on early (early, Е) and late (late, L) sites. The early fragment includes genes Е1-Е7 coding synthesis of fibers, responsible{crucial} for various functions in process репликации a virus and transformation of cells{cages}. Genes Е1 and Е2 are responsible{crucial} for репликацию a virus, and also participate in regulation of a transcription virus генома. The product of gene Е1 is responsible for maintenance персистенции virus генома in эписомальной to the form. Gene Е2 codes products which can as a trance - activate, and to suppress экспрессию early genes and энхенсерных sites URR. Трансактивирующий the factor is identified in precancer changes шейки a uterus, репрессирующий the factor in vivo is not identified [16]. Gene Е4 participates during maturing virus particles, genes Е5-Е7 possess трансформирующим potential. Genes Е6 and Е7 are always defined{determined} and экспрессируются in tumours шейки a uterus and received of tumours шейки a uterus cellular lines. The biological effect трансформирующего potential of genes Е6 and Е7 will be considered below. The late fragment генома will consist of genes L1 and L2, coding structural fibers вириона [5,21]. Подробнее...

The opportunity of interrelation неоплазий шейки a uterus with venereal diseases was for many years discussed. In group of the women suffering инвазивным РШМ, higher frequency of revealing of nonspecific microflora is marked, switching трихомонадные and гарднерелловы infections [3,6]. Examples of such influence were discussed in attitude{relation} Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, a virus of a simple herpes of type 2, a cytomegalovirus, a virus of a papilloma of the person [3,19]. Epidemiological researches have convincingly shown, that a conclusive risk factor of occurrence of precancer changes and a cancer шейки a uterus is генитальная папилломавирусная the infection, accompanying папилломавирусной infections of sexual ways influence at early stages of development неоплазий and do not influence on already arisen РШМ [5,13,14,23]. Подробнее...