нии онкологии профилактика рака молочной железы
The authentic establishment of association папилломавирусов with development генитальной неоплазии has allowed to approach closely to an opportunity to analyze complex{difficult} and questions at issue of correlation caused ВПЧ молекулярно-genetic changes with clinical features and forecast РШМ. Clinical current РШМ is influenced with histologic type and a degree of a differentiation of a tumour, the size of a primary tumour, depth инвазии subject fabrics and involving in tumoral process прилежащих to шейке a uterus of fabrics, лимфососудистого spaces and регионарных лимфоузлов. Forecast РШМ the big sizes of a primary tumour, a low degree of a differentiation of a tumour, presence of metastatic defeat регионарных лимфоузлов worsen, young age of patients [2,14]. Messages, соотносящие молекулярно-genetic determinants of the ВПЧ-INFECTION at РШМ with гистопатологическими both clinical features of tumours and forecast РШМ, contain inconsistent results. ВПЧ type 16 meets in высокодифференцированных плоскоклеточных tumours while ВПЧ type 18 it is associated with плоскоклеточными tumours of a low degree of a differentiation and аденокарциномами [13,14] is more often. Подробнее...
Modern молекулярно-trouble-shooting tests quickly move ahead in a direction of increase of their sensitivity and specificity. Now for identification virus ДНК various techniques of hybridization ДНК and molecular cloning are used. The most sensitive method now recognizes полимеразная chain reaction with типоспецифическими and species-specific праймерами, allowing to reveal virus sequences in геноме cells{cages} of tumours шейки a uterus in 95-100 % of cases [5,14,18,22]. Now it is identified more than 100 types ВПЧ, are in detail described more than 70 types, the fact is fixed, that certain types ВПЧ can infect strictly certain kind эпителия and to cause characteristic changes. Revealing of multi-variant approach of genotypes ВПЧ and identification of the data specific accumulation about malignant transformation генитальных кондилом have allowed to consider{examine} папилломавирус as possible{probable} этиологический the factor of development РШМ [13,15,20,23]. Подробнее...
