гипертермия в онкологии

Depth инвазии tumours, defeat of lymphatic vessels and units, параметральная and влагалищная инфильтрация do not depend from молекулярно-genetic a determinant of infection ВПЧ [14]. Кing (1989) has not found out communication{connection} between type ВПЧ revealed in a tumour and frequency of metastasises in регионарные лимфоузлы, Girardi (1992) observed more often defeat параметриев and лимфоузлов in cases, positive on ВПЧ type 16. Results of researches Sebbelov (1991), Kentner (1993), Ikenberg (1994) have not shown association between молекулярно-genetic determinants of infection ВПЧ and the forecast, in works Walker (1989) and Burnett (1992) is informed on much worse forecast in cases, positive on ВПЧ type 18 [цит. On 14]. However the majority of researches includes no more than 100 cases, thus definition of presence of virus sequences was made by a method of блот-hybridization on Саузерну, allowing to reveal fragments генома ВПЧ no more than in 75 % of cases РШМ [14]. Подробнее...

Long enough time dominated the opinion based on statement R.Meyer (1910) about trauma as этиологическом the moment of metaplastic changes эпителия шейки of a uterus. G.Ward (1935) counted, what not breaks шейки a uterus in themselves, and the subsequent infection conducting{leading} to a chronic inflammation, is этиологическим the moment in development карцином. Howard (1951) at research of histologic preparations шейки a uterus at the confirmed inflammation found out метаплазию эпителия in 83 % of cases. A.I.Serebrov (1957) wrote: " ... Not smaller value, than a mechanical trauma, in патогенезе a cancer шейки a uterus has a local infection, more truly, a combination of these two conditions ". Modern epidemiological researches have confirmed these assumptions, having allocated as risk factors РШМ the early beginning of a sexual life, early the first роды, often change of sexual partners, venereal diseases (including at sexual partners). Use of modern methods of contraception also is discussed as a possible{probable} risk factor of a gynecologic cancer. It is established, that use of barrier methods of contraception results in authentic decrease{reduction} in desease РШМ [3,5,14,22,23], application внутриматочных contraceptives does not render influence on desease РШМ [6]. Подробнее...