нии детской онкологии и гематологии

For acknowledgement{confirmation} of some positions it is necessary to continue molecular and цитогенетические researches on all tumours аногенитальной the zones, connected with ВПЧ. Now, after accumulation of a plenty epidemiological and эксперементальных the data, РШМ it is represented by unique model for studying virus канцерогенеза and definitions of associations between молекулярно-genetic changes caused by a virus and features of clinical current and the forecast of disease. Подробнее...

Process of integration is accompanied by partial loss of a genetic material of a virus, thus virus a gene irrespective of делеций loses ability to full репликации, and in the cells{cages} containing integrated cellular gene, there is no production of virus particles. Assume, that integration represents активационный the mechanism of a progression неоплазии from дисплазии a heavy degree to a cancer; she{it} originally carries поликлональный character. Most frequently in канцерогенез шейки a uterus are involved certain{determined} speed up chromosomes 5,6,10,11 and 17. Integration virus ДНК induces instability cellular генома and as consequence{investigation} an induction of infringements in the various chromosomes tested on loss of heterozygosity. The site of primary integration virus ДНК is not determined, quite often it{he} settles down near to cellular онкогенов [4]. Подробнее...