детские лейкозы

Middle age of patients has made 64 years; 84 % had positive рецепторный the status, 34 % - positive axillary лимфоузлы, 21 % of patients received адъювантную chemotherapy earlier. Reception анастрозола associated with reduction of risk рецидивирования on 17 % (1 % in absolute values) in comparison with тамоксифеном (р=0,0129); the combination анастрозола and тамоксифена did not differ on efficiency from monotherapy тамоксифеном. It is necessary to note, that reception анастрозола associated also with essential decrease{reduction} in risk of development контралатерального a cancer dairy железы (р=0,0068). Костно-muscular pains, and also crises of bones much more often were observed in group анастрозола while тромбоэмболические episodes and gynecologic complications, including a cancer эндометрия, much more often met in group тамоксифена. Thus, анастрозол it can be considered{examined} as alternative тамоксифену at patients in менопаузе with positive receptors. Reception анастрозола has considerably lowered frequency of development контралатерального a cancer, and this fact is the basis for studying group ингибиторов ароматазы as means of preventive maintenance of a cancer dairy железы in groups with the raised{increased} risk. Подробнее...

Онкогенный the potential папилломавирусов essentially varies; on ability to initiate диспластические (precancer) changes and a cancer папилломавирусы are conditionally divided{shared} into groups of "high" and "low" risk of occurrence of tumoral transformation infected эпителия. Types ВПЧ 6,11, 42, 43, 44 have been classified as types of low risk of development of a cancer, types 16, 18, 48, 56 - high risk. So, ВПЧ types 6 and 11 are the reason peaked кондилом, are frequently identified at дисплазиях easy and average degrees of weight and are seldom connected to tumours шейки a uterus. ВПЧ types 16 and 18 prevail of other types папилломавирусов at РШМ, ВПЧ type 16 comes to light in 50-70 % of cases, in 10-20 % comes to light ВПЧ type 18, other types ВПЧ of high risk come to light much less often [13,14,21]. Most frequently meeting 16 type of a virus is determined, it{he} is revealed in 21 % of cases CIN-I, in 57 % of cases CIN-II-III. With an infection types of a virus 16 and 18 associate 67-93 % of cases РШМ, the virus of type 18 is found out approximately in 2 times less often than a virus of type 16 [11,13.15,18]. The virus of a papilloma of type 18 is associated with development аденокарцином, has higher онкогенный potential, with it{him} connect fast rate of a tumoral progression, a low level of a differentiation infected эпителия, the adverse forecast others онкогенными types [12,14]. Подробнее...