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Researchers from Center MD Anderson in 1998 publish 5-years results of treatment of patients инвазивным cancer I-II of a stage with one-stage reconstruction, also having divided{shared} patients on two groups as executed мастэктомии with one-stage reconstruction - with preservation of a leather{skin} (104 patients) and without (27 patients) [36]. The percent{interest} of local relapses has made accordingly - 6,7 % and 7,4 %, system progressing of illness of 12,5 % against 25,9 % in group standard мастэктомии, parameters безрецидивной and the general{common} survival rate in the first group have made 88,5 % and 80,8 %, and in the second 74,1 % and 55,6 %. Certainly, in the given situation it is possible to think of absence of impartiality of the surgeons choosing methods for treatment of those or other patients when the patient with more worse forecast carried out standard operative interventions. Подробнее...

Thus, gene Е6 is multifunctional fiber, трансактивирующая which activity assumes participation in regulation of a transcription, interaction with a gene р53, his{its} degradation, in infringement of the mechanism of the control of cellular growth and process of a differentiation of cells{cages}. However till now there is no harmonous representation about the mechanism of interaction of virus fiber Е6 with cellular fibers in vivo. Virus fiber Е7 cooperates with cellular fiber Rb105, Rb-related fibers and Н1-киназой. These interactions are the independent processes necessary for effective transformation of cells{cages} by fiber. Fiber pRb (р105) is a product of a gene ретинобластомы, супрессора cellular growth. Подробнее...