лейкемия и лейкоз

Break of a ring molecule virus ДНК can occur in any place, however most frequently - in area Е1/Е2; exception is area URR-Е6-Е7, which интактна as in морфологически not changed эпителии and at дисплазиях, and in tumoral cells{cages}. Disappearance супрессорной causes functions of virus fiber Е2 суперэкспрессию virus онкогенов Е6-Е7, трансформирующее which action promotes a progression неоплазий. It is supposed, that gene Е1 participates in suppression of the virus promotor, consequence{investigation} of a mutation of gene Е1 are activation of a transcription virus генома and increase трансформирующей activity virus онкогенов [16,23]. Подробнее...

The authentic establishment of association папилломавирусов with development генитальной неоплазии has allowed to approach closely to an opportunity to analyze complex{difficult} and questions at issue of correlation caused ВПЧ молекулярно-genetic changes with clinical features and forecast РШМ. Clinical current РШМ is influenced with histologic type and a degree of a differentiation of a tumour, the size of a primary tumour, depth инвазии subject fabrics and involving in tumoral process прилежащих to шейке a uterus of fabrics, лимфососудистого spaces and регионарных лимфоузлов. Forecast РШМ the big sizes of a primary tumour, a low degree of a differentiation of a tumour, presence of metastatic defeat регионарных лимфоузлов worsen, young age of patients [2,14]. Messages, соотносящие молекулярно-genetic determinants of the ВПЧ-INFECTION at РШМ with гистопатологическими both clinical features of tumours and forecast РШМ, contain inconsistent results. ВПЧ type 16 meets in высокодифференцированных плоскоклеточных tumours while ВПЧ type 18 it is associated with плоскоклеточными tumours of a low degree of a differentiation and аденокарциномами [13,14] is more often. Подробнее...