онкология кожи

Process of integration is accompanied by partial loss of a genetic material of a virus, thus virus a gene irrespective of делеций loses ability to full репликации, and in the cells{cages} containing integrated cellular gene, there is no production of virus particles. Assume, that integration represents активационный the mechanism of a progression неоплазии from дисплазии a heavy degree to a cancer; she{it} originally carries поликлональный character. Most frequently in канцерогенез шейки a uterus are involved certain{determined} speed up chromosomes 5,6,10,11 and 17. Integration virus ДНК induces instability cellular генома and as consequence{investigation} an induction of infringements in the various chromosomes tested on loss of heterozygosity. The site of primary integration virus ДНК is not determined, quite often it{he} settles down near to cellular онкогенов [4]. Подробнее...

Инфицированность ВПЧ type 18 contacts the worse forecast Walker (1989) and Burnett (1992), Riou (1990) and Higgins (1991) specify higher parameters of death rate in case of ВПЧ-NEGATIVE tumours, in researches Hоweey (1991), Sebbelov (1991), Chen (1993), Ikenberg (1994) similar law has not been revealed [цит. On 14]. However results of similar researches are put under doubt by the modern data on revealing sequences virus генома a method полимеразной chain reaction in 95-100 % of cases плоскоклеточного a cancer and аденокарцином шейки a uterus [18,23]. The age of patients, on one data, is not connected to молекулярно-genetic determinants of infection ВПЧ while other authors specify, that ВПЧ type 18 or ВПЧ type 16 come to light at younger patients is more often. Stage FIGO, by results of one researches, has not been connected to молекулярно-genetic determinants of infection ВПЧ [14,18]. Подробнее...