дерматоскопия меланомы

For the first time serious assumptions of a possible{probable} role of viruses of papillomas in development РШМ have been stated in the middle of 70th years. It is necessary to emphasize, that definition of concept " a virus as этиологический the factor of development of a tumour " is based on a combination of the following criteria: 1) regular detection in tumoral cells{cages} virus ДНК (both in integrated, and in эписомальной to the form); 2) клонированные virus genes in cellular systems in vitro should induce malignant transformation of cells{cages}, including cells{cages} of the person; 3) regular экспрессия virus genes in tumoral cells{cages}; 4) existence in the nature of the similar viruses, capable to induce formation{education} of tumours at эксперементальных animals; 5) the epidemiological data confirming communication{connection} between tumoral process and presence of a virus genetic material in tumoral cells{cages}. The technique of molecular cloning has allowed to create a physical card{map} of viruses with the help эндонуклеаз, to define{determine} a site and sequence of the proteins coded by a virus [13,19.] has been shown, that in cells{cages} РШМ by a gene of a virus is actively transcribed, and crucial importance for development РШМ has персистенция virus генома [23]. The cellular lines received from a tumoral fabric шейки of a uterus, allow to carry out{spend} the comparative analysis of lines and tumours on персистенцию virus ДНК, function and экспрессию genes ДНК of a virus of a papilloma of person (ВПЧ). In fabrics эпителиальных дисплазий and карцином шейки a uterus during tumoral transformation regulation of a transcription virus онкогенов is broken, that is shown by quantitative distinctions in экспрессии early genes Е6 and Е7, playing the basic role in an induction of malignant growth of cells{cages} [22]. Подробнее...

In this aspect interest work Newman [37] devoted to local relapses after operations of similar type also deserves. At 372 patients with a cancer dairy железы T1, T2, for the period with 1986 till 1993, relapses have been marked at 23 sick (6,2 %) with the average period of occurrence 25 мес and in 96 % of cases have been submitted by palpated formations{educations} in a leather{skin} dairy железы. At 14 patients relapse has been subjected surgical иссечению in a combination with system therapy. The resection reconstructed железы has been executed at three patients. The full local control has been achieved at 74 % of patients. At nine (39 %) have developed the remote metastasises. At average term of supervision 26 мес 14 from 23 patients (61 %) are alive without attributes of illness, 7 (30 %) have died. Подробнее...