инвазивный рак шейки матки

In summary it is necessary to note, that РШМ is unique model associated with a virus infection канцерогенеза. Uniqueness of her{it} is defined{determined} by constant presence at tumoral cells{cages} экзогенной the genetic information possessing трансформирующим in potential, presence of experimental acknowledgement{confirmation} of a role трансформирующих virus genes in an induction of the transformed phenotype and accumulation of a plenty of the epidemiological data confirming communication{connection} between tumoral процесом and presence of a virus genetic material. Подробнее...

Virus fiber Е7 is capable to break regulation of the control клеточого a cycle, forming a stable inactive complex with a series of fibers regulating a cellular cycle; stimulates succession of events in a S-phase of a cellular cycle by инициации репликации virus genes and infringement of regulation пролиферации the transformed cells{cages}. The opportunity of uncontrollable synthesis cellular ДНК under influence of fiber Е7 is supposed. Thus, fiber Е7 is multifunctional due to interaction with cellular fibers; fiber Е7 is capable to cancel a stop of cells{cages} in a G1-phase of a cellular cycle, to render митогенное influence and to stimulate uncontrollable synthesis ДНК [12,13,16,22]. Подробнее...