химиотерапия рак яичники

During tumoral transformation the key role is played with virus genes Е6 and Е7 which activity is supervised регуляторным by site URR. This site генома contains area of the virus promotor, a locus репликации, энхенсерные elements, активирующие the sequences necessary for репликации virus ДНК, sites of linkage for fiber Е2, cellular factors of a transcription, receptors of a progesterone and глюкокортикоидных hormones [16]. In регуляторной areas генома the promotor р97 (ВПЧ type 16), р105 (ВПЧ type 18), regulating экспрессию virus genes settles down; activity of the promotor is adjusted by virus and cellular fibers. Онкобелок Е6 plays a role коактиватора, cooperating with factors of a transcription and elements of the basic транскрипционного a complex. Подробнее...

Viruses of papillomas concern to family паповавирусов (Papovaviridae) and represent group of the viruses amazing large horned livestock, birds and the person which are capable to infect базальные cells{cages} of a leather{skin} and flat эпителия. Папилломавирусы - one of the most heterogeneous groups of viruses which criterion of a differentiation is the degree of genetic relationship of viruses according to molecular hybridization: she{it} can change from 10 up to 85 %. Diameter of virus particles of 55 nanometers. The virus has no external environment. Капсид a virus will consist from 72 капсомеров. The detailed analysis of molecule ДНК ВПЧ became possible{probable} after development of a technique of splitting ДНК with use эндонуклеаз and the analysis of these fragments with the help gel - электрофореза. The given method has allowed to define{determine} characteristic pictures of splitting ДНК and to create a physical card{map} of an arrangement of points of splitting in геноме various папилломавирусов [20]. Подробнее...