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With increase in quantity{amount} of people of elderly and senile age, decrease{reduction} in death rate from other diseases, неминуемо desease a cancer and death rate from him{it} will grow. Under forecasts of the World organization of public health services (CART) desease and death rate oncological diseases all over the world will increase in 2 times for the period since 1999 for 2020: with 10 up to 20 million new cases and with 6 up to 12 million registered death. Подробнее...

Thus, gene Е6 is multifunctional fiber, трансактивирующая which activity assumes participation in regulation of a transcription, interaction with a gene р53, his{its} degradation, in infringement of the mechanism of the control of cellular growth and process of a differentiation of cells{cages}. However till now there is no harmonous representation about the mechanism of interaction of virus fiber Е6 with cellular fibers in vivo. Virus fiber Е7 cooperates with cellular fiber Rb105, Rb-related fibers and Н1-киназой. These interactions are the independent processes necessary for effective transformation of cells{cages} by fiber. Fiber pRb (р105) is a product of a gene ретинобластомы, супрессора cellular growth. Подробнее...