доброкачественная меланома

The opportunity of interrelation неоплазий шейки a uterus with venereal diseases was for many years discussed. In group of the women suffering инвазивным РШМ, higher frequency of revealing of nonspecific microflora is marked, switching трихомонадные and гарднерелловы infections [3,6]. Examples of such influence were discussed in attitude{relation} Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, a virus of a simple herpes of type 2, a cytomegalovirus, a virus of a papilloma of the person [3,19]. Epidemiological researches have convincingly shown, that a conclusive risk factor of occurrence of precancer changes and a cancer шейки a uterus is генитальная папилломавирусная the infection, accompanying папилломавирусной infections of sexual ways influence at early stages of development неоплазий and do not influence on already arisen РШМ [5,13,14,23]. Подробнее...

During tumoral transformation the key role is played with virus genes Е6 and Е7 which activity is supervised регуляторным by site URR. This site генома contains area of the virus promotor, a locus репликации, энхенсерные elements, активирующие the sequences necessary for репликации virus ДНК, sites of linkage for fiber Е2, cellular factors of a transcription, receptors of a progesterone and глюкокортикоидных hormones [16]. In регуляторной areas генома the promotor р97 (ВПЧ type 16), р105 (ВПЧ type 18), regulating экспрессию virus genes settles down; activity of the promotor is adjusted by virus and cellular fibers. Онкобелок Е6 plays a role коактиватора, cooperating with factors of a transcription and elements of the basic транскрипционного a complex. Подробнее...