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Инфицированность ВПЧ type 18 contacts the worse forecast Walker (1989) and Burnett (1992), Riou (1990) and Higgins (1991) specify higher parameters of death rate in case of ВПЧ-NEGATIVE tumours, in researches Hоweey (1991), Sebbelov (1991), Chen (1993), Ikenberg (1994) similar law has not been revealed [цит. On 14]. However results of similar researches are put under doubt by the modern data on revealing sequences virus генома a method полимеразной chain reaction in 95-100 % of cases плоскоклеточного a cancer and аденокарцином шейки a uterus [18,23]. The age of patients, on one data, is not connected to молекулярно-genetic determinants of infection ВПЧ while other authors specify, that ВПЧ type 18 or ВПЧ type 16 come to light at younger patients is more often. Stage FIGO, by results of one researches, has not been connected to молекулярно-genetic determinants of infection ВПЧ [14,18]. Подробнее...

To this time concern definition Melnick (1952), A.D.Timofeevskim (1961) with the help of электронно-microscopic technics{technical equipment} of constant presence вирусоподобных телец in папиллломах. Barrett (1954) has established the fact of transfer генитальных кондилом at гетеросексуальных the sexual relations, Dunn and Ogilvie (1968) have allocated virus particles from генитальных warts [4,9]. As the characteristic of cytologic changes in эпителии шейки a uterus, observable at папилломатозе, Aure (1949) described перинуклеарные changes in cells{cages} at research мазков with шейки a uterus. For the description of similar changes Koss, Durfee (1956) have entered into clinical practice the term " койлоцитотическая атипия " for which large cells{cages} with rather small гиперхромным a nucleus surrounded with transparent cytoplasm are characteristic. Authors for the first time have noted communication{connection} between койлоцитотической атипией. дисплазией and РШМ. Woodruff, Peterson (1958) and Pitkin, Kent (1963) have described histologic characteristics of classical forms папилломатозных кондилом; long time папилломатозные кондиломы were considered as unique morphological display папилломавирусной infections of sexual ways [9,10]. Подробнее...