рак толстого кишечника
Originally in researches GOG 111 and OV-10 it has been shown, that паклитаксел in a combination with цисплатином essentially improve results of treatment in comparison with a combination цисплатин-циклофосфан. High нейротоксичность combinations цисплатин-паклитаксел has made actual replacement цисплатина on карбоплатин. In several researches [Neijt J.P., AGO, GOG-158] it has been shown, that such replacement does not result in deterioration of the remote results and essentially improves bearableness of treatment. Then in research GOG-132 it is revealed, that at purpose{assignment} as combinations паклитаксела and цисплатина, and consecutive use of two preparations (цисплатина for the first line and паклитаксела for the second line), life expectancy of patients is identical. Thus, necessity of use таксанов at various stages of treatment for achievement of the best results has been once again underlined. Подробнее...
The first researches devoted эпидемиологии РШМ, have appeared in a century. Rigoni-Stern in 1842 has published the data based on studying of the register of death in Verona with 1760 on 1830. It{he} has noticed, that РШМ much more often caused death of married women and widows and did not meet at virgins and монахинь. This circumstance has allowed the scientist to state a hypothesis about infectious origin РШМ. Known interest submit data, published F.Gagnon (1950), - at studying 13000 case records монахинь Montreal and Quebec РШМ has not been found out never. The author connected similar results with low frequency of inflammatory diseases шейки a uterus at монахинь. In review Mogaji (1973) it is shown, that гистологически confirmed плоскоклеточный РШМ at virgins represents an exclusive rarity, these data are confirmed with researches Kessler (1976) and Skoqg (1982). Results of the epidemiological researches concerning a role in occurrence РШМ of the early beginning of a sexual life, early first pregnancy, often change of sexual partners, and also the infectious diseases transmitted in the sexual way are published. Подробнее...
