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During many years was considered, that usual, flat (ювенильные) and генитальные warts are caused by one type папилломавируса, and distinctions in clinical current are caused by distinctions in localization. Sights at a pathology кондилом шейки a uterus have been considerably reconsidered after Meisels, Fortin (1976), Purola, Savia (1976) have described генитальные flat and inverted (эндофитные) кондиломы, having defined{determined} their basic difference from кондилом other localizations, and postulated цитоморфологические attributes папилломавирусной infections: коилоцитоз or баллонирование the cells{cages}, described increased, гиперхромными the nucleus surrounded with a precise zone of light cytoplasm. Later with the help электронно-microscopic, иммуногистохимических and ДНК-гибридизационных researches it has been confirmed them папилломавирусная этиология [9,20]. Подробнее...

In research AGO-GINECO authors have estimated expediency of addition антрациклинов to a combination карбоплатин паклитаксел. Inclusion эпирубицина has strengthened toxicity of a combination, but has not improved results of therapy [10]. In research SCOTROC comparison available today in our disposal таксанов is made: паклитаксела and доцетаксела [11]. Both preparations in a combination with карбоплатином have shown identical frequency of objective effects and time before progressing. The combination карбоплатин-паклитаксел possessed more expressed нейротоксичностью while карбоплатин-доцетаксел caused development нейтропении is more often. Подробнее...