липосомальная онкология

Considering these data, in the beginning of 90th the first publications published by several surgeons which concerned changes of traditional cuts{sections} at modified radical мастэктомии with the purpose of improvement of results of one-stage reconstruction dairy железы have appeared. In particular, the first work on this theme has been published in magazine " Plastic and Reconstructive Surgery " in 1990 Toth et al. in section " Ideas and innovations " [28]. In this work the case of one-stage reconstruction of both dairy желез concerning a mucous cancer right dairy железы at the patient with risk of development of a cancer in another dairy iron has been submitted. In connection with that at the patient dairy железы were sizable in a combination with expressed птозом, it has been executed modified radical мастэктомия with cuts{sections} on type редукционной plastics and preventive мастэктомия at the left with one-stage reconstruction билатеральным completely деэпителизированным cross-section ректо-абдоминальным (TРAM) a rag c good aesthetic result. In one year, the same group of surgeons publishes the report on 17 patients with which one-stage reconstruction c has been executed by application of a similar technique which the author has named " Wise pattern " with use of various techniques of reconstruction. In this work the term " мастэктомия with preservation of a leather{skin} " for the first time has sounded, and also principles of performance of similar operative interventions have been sounded. These principles included: 1) Removal{Distance} of all fabric dairy железы 2) removal{distance} сосково-ареолярного a complex 3) removal{distance} of a leather{skin} in a projection preoperative биопсии 4) an opportunity to execute axillary лимфаденэктомию from the same access. Подробнее...

For the first time serious assumptions of a possible{probable} role of viruses of papillomas in development РШМ have been stated in the middle of 70th years. It is necessary to emphasize, that definition of concept " a virus as этиологический the factor of development of a tumour " is based on a combination of the following criteria: 1) regular detection in tumoral cells{cages} virus ДНК (both in integrated, and in эписомальной to the form); 2) клонированные virus genes in cellular systems in vitro should induce malignant transformation of cells{cages}, including cells{cages} of the person; 3) regular экспрессия virus genes in tumoral cells{cages}; 4) existence in the nature of the similar viruses, capable to induce formation{education} of tumours at эксперементальных animals; 5) the epidemiological data confirming communication{connection} between tumoral process and presence of a virus genetic material in tumoral cells{cages}. The technique of molecular cloning has allowed to create a physical card{map} of viruses with the help эндонуклеаз, to define{determine} a site and sequence of the proteins coded by a virus [13,19.] has been shown, that in cells{cages} РШМ by a gene of a virus is actively transcribed, and crucial importance for development РШМ has персистенция virus генома [23]. The cellular lines received from a tumoral fabric шейки of a uterus, allow to carry out{spend} the comparative analysis of lines and tumours on персистенцию virus ДНК, function and экспрессию genes ДНК of a virus of a papilloma of person (ВПЧ). In fabrics эпителиальных дисплазий and карцином шейки a uterus during tumoral transformation regulation of a transcription virus онкогенов is broken, that is shown by quantitative distinctions in экспрессии early genes Е6 and Е7, playing the basic role in an induction of malignant growth of cells{cages} [22]. Подробнее...