онкология урология

Break of a ring molecule virus ДНК can occur in any place, however most frequently - in area Е1/Е2; exception is area URR-Е6-Е7, which интактна as in морфологически not changed эпителии and at дисплазиях, and in tumoral cells{cages}. Disappearance супрессорной causes functions of virus fiber Е2 суперэкспрессию virus онкогенов Е6-Е7, трансформирующее which action promotes a progression неоплазий. It is supposed, that gene Е1 participates in suppression of the virus promotor, consequence{investigation} of a mutation of gene Е1 are activation of a transcription virus генома and increase трансформирующей activity virus онкогенов [16,23]. Подробнее...

The cellular lines received from tumours, and биоптаты from патологически the changed fabrics long time remained a unique material for studying mechanisms папилломавирусной infections. Unsuccessfulness of reproduction папилломавируса in culture of cells{cages}, absence convincing серологических tests for a virus infection, variety of displays цитопатических effects of a virus and subjectivity of an estimation and interpretation a virus - induced cytologic and гистопатологических changes constrained the further researches. Подробнее...