нии онкологии рф

Virus fiber Е7 is capable to break regulation of the control клеточого a cycle, forming a stable inactive complex with a series of fibers regulating a cellular cycle; stimulates succession of events in a S-phase of a cellular cycle by инициации репликации virus genes and infringement of regulation пролиферации the transformed cells{cages}. The opportunity of uncontrollable synthesis cellular ДНК under influence of fiber Е7 is supposed. Thus, fiber Е7 is multifunctional due to interaction with cellular fibers; fiber Е7 is capable to cancel a stop of cells{cages} in a G1-phase of a cellular cycle, to render митогенное influence and to stimulate uncontrollable synthesis ДНК [12,13,16,22]. Подробнее...

From all identified types of viruses of papillomas 34 are associated with defeat аногенитальной areas. Viruses of papillomas infect базальные layers эпителия (the most "vulnerable" site the zone of transition multilayered flat эпителия in cylindrical эпителий is). Caused патоморфологические changes Kurz (1993) and Schiffman (1994) are classified by viruses as: 1) good-quality атипия; 2) LSIL (Low-grade Squamous Intraepithelial Lesions) or CIN-I (Cervical Intraepithelial Neoplasia) - дисплазия an easy degree without койлоцитоза or with attributes койлоцитоза; 3) HSIL (High-grade Squamous Intraepithelial Lesions), CIN-II-moderate дисплазия; 4) expressed дисплазия or интраэпителиальный a cancer (in situ) - CIN-III. Discussion concerning classification дисплазии and преинвазивного РШМ till now proceeds. In the domestic literature it is accepted to allocate three degrees of weight дисплазии эпителия шейки a uterus, интраэпителиальный РШМ it is allocated into separate group [10]. The group дисплазий эпителия шейки a uterus is heterogeneous both with патоморфологической, and from the virologic point of view. Now there is no confidence, that various degrees дисплазий are stages канцерогенеза [18]. Подробнее...