онкология рак щитовидной железы

To this time concern definition Melnick (1952), A.D.Timofeevskim (1961) with the help of электронно-microscopic technics{technical equipment} of constant presence вирусоподобных телец in папиллломах. Barrett (1954) has established the fact of transfer генитальных кондилом at гетеросексуальных the sexual relations, Dunn and Ogilvie (1968) have allocated virus particles from генитальных warts [4,9]. As the characteristic of cytologic changes in эпителии шейки a uterus, observable at папилломатозе, Aure (1949) described перинуклеарные changes in cells{cages} at research мазков with шейки a uterus. For the description of similar changes Koss, Durfee (1956) have entered into clinical practice the term " койлоцитотическая атипия " for which large cells{cages} with rather small гиперхромным a nucleus surrounded with transparent cytoplasm are characteristic. Authors for the first time have noted communication{connection} between койлоцитотической атипией. дисплазией and РШМ. Woodruff, Peterson (1958) and Pitkin, Kent (1963) have described histologic characteristics of classical forms папилломатозных кондилом; long time папилломатозные кондиломы were considered as unique morphological display папилломавирусной infections of sexual ways [9,10]. Подробнее...

From all identified types of viruses of papillomas 34 are associated with defeat аногенитальной areas. Viruses of papillomas infect базальные layers эпителия (the most "vulnerable" site the zone of transition multilayered flat эпителия in cylindrical эпителий is). Caused патоморфологические changes Kurz (1993) and Schiffman (1994) are classified by viruses as: 1) good-quality атипия; 2) LSIL (Low-grade Squamous Intraepithelial Lesions) or CIN-I (Cervical Intraepithelial Neoplasia) - дисплазия an easy degree without койлоцитоза or with attributes койлоцитоза; 3) HSIL (High-grade Squamous Intraepithelial Lesions), CIN-II-moderate дисплазия; 4) expressed дисплазия or интраэпителиальный a cancer (in situ) - CIN-III. Discussion concerning classification дисплазии and преинвазивного РШМ till now proceeds. In the domestic literature it is accepted to allocate three degrees of weight дисплазии эпителия шейки a uterus, интраэпителиальный РШМ it is allocated into separate group [10]. The group дисплазий эпителия шейки a uterus is heterogeneous both with патоморфологической, and from the virologic point of view. Now there is no confidence, that various degrees дисплазий are stages канцерогенеза [18]. Подробнее...