лечение онкологии поджелудочной железы

In this aspect interest work Newman [37] devoted to local relapses after operations of similar type also deserves. At 372 patients with a cancer dairy железы T1, T2, for the period with 1986 till 1993, relapses have been marked at 23 sick (6,2 %) with the average period of occurrence 25 мес and in 96 % of cases have been submitted by palpated formations{educations} in a leather{skin} dairy железы. At 14 patients relapse has been subjected surgical иссечению in a combination with system therapy. The resection reconstructed железы has been executed at three patients. The full local control has been achieved at 74 % of patients. At nine (39 %) have developed the remote metastasises. At average term of supervision 26 мес 14 from 23 patients (61 %) are alive without attributes of illness, 7 (30 %) have died. Подробнее...

The direction of action of fiber Е6 (супрессорное or трансактивирующее) is defined{determined} by character, position and number of sites of linkage транскрипционных factors in promotors. The promotor р97 (ВПЧ type 16) can play a role in maintenance of a latent condition of a virus infection. With онкобелком Е6 ВПЧ types 16 and 18 7 cellular fibers cooperate at least, now from them 3 cellular fibers are identified: р53, Е6-АР, Е6-ВР. The gene р53 is associated both with the control of cellular growth, and with неопластической transformation; делеции or mutations in some cases transform р53 in active онкоген. Not all malignant tumours have mutations р53, the alternative mechanism инактивации р53 however is proved by linkage with онкобелком Е6 ВПЧ types 16 and 18, that results in loss of the control for пролиферацией cells{cages}. Cellular fiber Е6-АР (Е6 associated protein) in a complex with онкобелком Е6 participates in degradation р53, and also, probably, shortens the period полужизни and reduces a level р53 in ВПЧ-иммортализованных cells{cages}. Fiber Е6-ВР (E6-binding protein) cooperates with gene Е6 ВПЧ of types 16 and 18, that in result results in inhibition of process of a differentiation of cells{cages} and, probably, creates conditions for репликации virus ДНК. Подробнее...