клиническая онкология

Viruses of papillomas concern to family паповавирусов (Papovaviridae) and represent group of the viruses amazing large horned livestock, birds and the person which are capable to infect базальные cells{cages} of a leather{skin} and flat эпителия. Папилломавирусы - one of the most heterogeneous groups of viruses which criterion of a differentiation is the degree of genetic relationship of viruses according to molecular hybridization: she{it} can change from 10 up to 85 %. Diameter of virus particles of 55 nanometers. The virus has no external environment. Капсид a virus will consist from 72 капсомеров. The detailed analysis of molecule ДНК ВПЧ became possible{probable} after development of a technique of splitting ДНК with use эндонуклеаз and the analysis of these fragments with the help gel - электрофореза. The given method has allowed to define{determine} characteristic pictures of splitting ДНК and to create a physical card{map} of an arrangement of points of splitting in геноме various папилломавирусов [20]. Подробнее...

In the first reviews the data on wide circulation ВПЧ in a population and his{its} expressed онкогенном potential [20] are submitted. Authors pay attention, that only инфицирования a virus of a papilloma it is not enough of one for an induction of tumoral growth, and specify a role кофакторов in ВПЧ-DEPENDENT канцерогенезе. Thus, ифекция a virus of a papilloma is necessary, but not a determinative of development of malignant process, иммортализации and transformations are involved in processes the cellular factors participating in regulation of a cellular cycle and a differentiation of cells{cages} [5,20,22]. Подробнее...