онкология хирургия

1491 patient with a cancer has taken part in research BCRIG01 dairy железы with positive axillary лимфоузлами; middle age has made 49 years, 62 % of patients had from 1 up to 3 лимфоузлов, at 69 % of a tumour were рецепторопозитивными on РЭ and РП, at 20 % - positive on HER2/neu. All patients having positive РЭ and РП, received also тамоксифен in a doze of 20 mg / ЯТФ. Within 5 years. The median of time of supervision at the moment of the analysis of results has made 33 (0-49) months. Подробнее...

During tumoral transformation the key role is played with virus genes Е6 and Е7 which activity is supervised регуляторным by site URR. This site генома contains area of the virus promotor, a locus репликации, энхенсерные elements, активирующие the sequences necessary for репликации virus ДНК, sites of linkage for fiber Е2, cellular factors of a transcription, receptors of a progesterone and глюкокортикоидных hormones [16]. In регуляторной areas генома the promotor р97 (ВПЧ type 16), р105 (ВПЧ type 18), regulating экспрессию virus genes settles down; activity of the promotor is adjusted by virus and cellular fibers. Онкобелок Е6 plays a role коактиватора, cooperating with factors of a transcription and elements of the basic транскрипционного a complex. Подробнее...