институт онкологии г москва

Originally in researches GOG 111 and OV-10 it has been shown, that паклитаксел in a combination with цисплатином essentially improve results of treatment in comparison with a combination цисплатин-циклофосфан. High нейротоксичность combinations цисплатин-паклитаксел has made actual replacement цисплатина on карбоплатин. In several researches [Neijt J.P., AGO, GOG-158] it has been shown, that such replacement does not result in deterioration of the remote results and essentially improves bearableness of treatment. Then in research GOG-132 it is revealed, that at purpose{assignment} as combinations паклитаксела and цисплатина, and consecutive use of two preparations (цисплатина for the first line and паклитаксела for the second line), life expectancy of patients is identical. Thus, necessity of use таксанов at various stages of treatment for achievement of the best results has been once again underlined. Подробнее...

In summary it is necessary to note, that РШМ is unique model associated with a virus infection канцерогенеза. Uniqueness of her{it} is defined{determined} by constant presence at tumoral cells{cages} экзогенной the genetic information possessing трансформирующим in potential, presence of experimental acknowledgement{confirmation} of a role трансформирующих virus genes in an induction of the transformed phenotype and accumulation of a plenty of the epidemiological data confirming communication{connection} between tumoral процесом and presence of a virus genetic material. Подробнее...