отделение онкологии

Depth инвазии tumours, defeat of lymphatic vessels and units, параметральная and влагалищная инфильтрация do not depend from молекулярно-genetic a determinant of infection ВПЧ [14]. Кing (1989) has not found out communication{connection} between type ВПЧ revealed in a tumour and frequency of metastasises in регионарные лимфоузлы, Girardi (1992) observed more often defeat параметриев and лимфоузлов in cases, positive on ВПЧ type 16. Results of researches Sebbelov (1991), Kentner (1993), Ikenberg (1994) have not shown association between молекулярно-genetic determinants of infection ВПЧ and the forecast, in works Walker (1989) and Burnett (1992) is informed on much worse forecast in cases, positive on ВПЧ type 18 [цит. On 14]. However the majority of researches includes no more than 100 cases, thus definition of presence of virus sequences was made by a method of блот-hybridization on Саузерну, allowing to reveal fragments генома ВПЧ no more than in 75 % of cases РШМ [14]. Подробнее...

Process of integration is accompanied by partial loss of a genetic material of a virus, thus virus a gene irrespective of делеций loses ability to full репликации, and in the cells{cages} containing integrated cellular gene, there is no production of virus particles. Assume, that integration represents активационный the mechanism of a progression неоплазии from дисплазии a heavy degree to a cancer; she{it} originally carries поликлональный character. Most frequently in канцерогенез шейки a uterus are involved certain{determined} speed up chromosomes 5,6,10,11 and 17. Integration virus ДНК induces instability cellular генома and as consequence{investigation} an induction of infringements in the various chromosomes tested on loss of heterozygosity. The site of primary integration virus ДНК is not determined, quite often it{he} settles down near to cellular онкогенов [4]. Подробнее...