лечение онкологи

The authentic establishment of association папилломавирусов with development генитальной неоплазии has allowed to approach closely to an opportunity to analyze complex{difficult} and questions at issue of correlation caused ВПЧ молекулярно-genetic changes with clinical features and forecast РШМ. Clinical current РШМ is influenced with histologic type and a degree of a differentiation of a tumour, the size of a primary tumour, depth инвазии subject fabrics and involving in tumoral process прилежащих to шейке a uterus of fabrics, лимфососудистого spaces and регионарных лимфоузлов. Forecast РШМ the big sizes of a primary tumour, a low degree of a differentiation of a tumour, presence of metastatic defeat регионарных лимфоузлов worsen, young age of patients [2,14]. Messages, соотносящие молекулярно-genetic determinants of the ВПЧ-INFECTION at РШМ with гистопатологическими both clinical features of tumours and forecast РШМ, contain inconsistent results. ВПЧ type 16 meets in высокодифференцированных плоскоклеточных tumours while ВПЧ type 18 it is associated with плоскоклеточными tumours of a low degree of a differentiation and аденокарциномами [13,14] is more often. Подробнее...

The decision on a choice of preparations for chemotherapy of the second line should be based, first of all, on definition of sensitivity of a tumour to derivatives of platinum after chemotherapy of the first line. The interval between the termination{ending} of therapy of the first line and progressing of disease more than 6 months testifies to high sensitivity of a tumour derivatives of platinum. Such patient for treatment of relapses should be appointed a combination of derivatives of platinum and new preparations from among that are used for carrying out of the second line of chemotherapy. At separate patients with duration of remission more than 12 months probably carrying out of chemotherapy of the second line by the same combination which was used at a stage of an induction. Frequency of objective effect at use of a combination of derivatives of platinum (is $more often карбоплатина in view of his{its} smaller toxicity) and new preparations makes 30-50 % at average life expectancy of sick 12-14 months. Подробнее...