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For the first time serious assumptions of a possible{probable} role of viruses of papillomas in development РШМ have been stated in the middle of 70th years. It is necessary to emphasize, that definition of concept " a virus as этиологический the factor of development of a tumour " is based on a combination of the following criteria: 1) regular detection in tumoral cells{cages} virus ДНК (both in integrated, and in эписомальной to the form); 2) клонированные virus genes in cellular systems in vitro should induce malignant transformation of cells{cages}, including cells{cages} of the person; 3) regular экспрессия virus genes in tumoral cells{cages}; 4) existence in the nature of the similar viruses, capable to induce formation{education} of tumours at эксперементальных animals; 5) the epidemiological data confirming communication{connection} between tumoral process and presence of a virus genetic material in tumoral cells{cages}. The technique of molecular cloning has allowed to create a physical card{map} of viruses with the help эндонуклеаз, to define{determine} a site and sequence of the proteins coded by a virus [13,19.] has been shown, that in cells{cages} РШМ by a gene of a virus is actively transcribed, and crucial importance for development РШМ has персистенция virus генома [23]. The cellular lines received from a tumoral fabric шейки of a uterus, allow to carry out{spend} the comparative analysis of lines and tumours on персистенцию virus ДНК, function and экспрессию genes ДНК of a virus of a papilloma of person (ВПЧ). In fabrics эпителиальных дисплазий and карцином шейки a uterus during tumoral transformation regulation of a transcription virus онкогенов is broken, that is shown by quantitative distinctions in экспрессии early genes Е6 and Е7, playing the basic role in an induction of malignant growth of cells{cages} [22]. Подробнее...

At patients РШМ earlier beginning of a sexual life is marked in comparison with control groups. Often change of sexual partners, early age of the first sorts [2,5,17] have adverse value. In a number of epidemiological and клинико-statistical researches decrease{reduction} in desease РШМ at women has been marked, whose husbands were exposed циркумцизии. This fact connected with possible{probable} cancerogenic action смегмы. Other authors have come out with the assumption of carcinogenicity contained in sperm гистона and протамина, capable in culture of a fabric to cause атипию multilayered flat эпителия шейки a uterus [3,4]. A number{line} of authors specify also some increase in desease инвазивным РШМ at women with a low social and economic level and the educational qualification [2,17], in other works such correlation is absent [3,14]. The factor of a heredity, significant at a cancer эндометря and яичников, at РШМ special does not play a role [2,3,8,14]. Till now the question on a role of the trauma connected to sorts and abortions, and contraceptive means as the moments contributing to development of tumours шейки of a uterus is discussed. Подробнее...