лимфобластный лейкоз

Viruses of papillomas concern to family паповавирусов (Papovaviridae) and represent group of the viruses amazing large horned livestock, birds and the person which are capable to infect базальные cells{cages} of a leather{skin} and flat эпителия. Папилломавирусы - one of the most heterogeneous groups of viruses which criterion of a differentiation is the degree of genetic relationship of viruses according to molecular hybridization: she{it} can change from 10 up to 85 %. Diameter of virus particles of 55 nanometers. The virus has no external environment. Капсид a virus will consist from 72 капсомеров. The detailed analysis of molecule ДНК ВПЧ became possible{probable} after development of a technique of splitting ДНК with use эндонуклеаз and the analysis of these fragments with the help gel - электрофореза. The given method has allowed to define{determine} characteristic pictures of splitting ДНК and to create a physical card{map} of an arrangement of points of splitting in геноме various папилломавирусов [20]. Подробнее...

The direction of action of fiber Е6 (супрессорное or трансактивирующее) is defined{determined} by character, position and number of sites of linkage транскрипционных factors in promotors. The promotor р97 (ВПЧ type 16) can play a role in maintenance of a latent condition of a virus infection. With онкобелком Е6 ВПЧ types 16 and 18 7 cellular fibers cooperate at least, now from them 3 cellular fibers are identified: р53, Е6-АР, Е6-ВР. The gene р53 is associated both with the control of cellular growth, and with неопластической transformation; делеции or mutations in some cases transform р53 in active онкоген. Not all malignant tumours have mutations р53, the alternative mechanism инактивации р53 however is proved by linkage with онкобелком Е6 ВПЧ types 16 and 18, that results in loss of the control for пролиферацией cells{cages}. Cellular fiber Е6-АР (Е6 associated protein) in a complex with онкобелком Е6 participates in degradation р53, and also, probably, shortens the period полужизни and reduces a level р53 in ВПЧ-иммортализованных cells{cages}. Fiber Е6-ВР (E6-binding protein) cooperates with gene Е6 ВПЧ of types 16 and 18, that in result results in inhibition of process of a differentiation of cells{cages} and, probably, creates conditions for репликации virus ДНК. Подробнее...