меланома дифдиагноз

Long enough time dominated the opinion based on statement R.Meyer (1910) about trauma as этиологическом the moment of metaplastic changes эпителия шейки of a uterus. G.Ward (1935) counted, what not breaks шейки a uterus in themselves, and the subsequent infection conducting{leading} to a chronic inflammation, is этиологическим the moment in development карцином. Howard (1951) at research of histologic preparations шейки a uterus at the confirmed inflammation found out метаплазию эпителия in 83 % of cases. A.I.Serebrov (1957) wrote: " ... Not smaller value, than a mechanical trauma, in патогенезе a cancer шейки a uterus has a local infection, more truly, a combination of these two conditions ". Modern epidemiological researches have confirmed these assumptions, having allocated as risk factors РШМ the early beginning of a sexual life, early the first роды, often change of sexual partners, venereal diseases (including at sexual partners). Use of modern methods of contraception also is discussed as a possible{probable} risk factor of a gynecologic cancer. It is established, that use of barrier methods of contraception results in authentic decrease{reduction} in desease РШМ [3,5,14,22,23], application внутриматочных contraceptives does not render influence on desease РШМ [6]. Подробнее...

The arsenal of the antineoplastic means used for carrying out of chemotherapy of the second line is extraordinary great. To them concern паклитаксел, доцетаксел, топотекан, липосомальный доксорубицин, пероральный этопозид, винорельбин, гемцитабин, оксалиплатин, алтретамин, ифосфамид. So big list of preparations is more likely the certificate of that any of them does not allow to reach{achieve} long remissions at the majority of patients. Efficiency of them changes from 12 up to 40 % at average life expectancy of 9-12 months. Подробнее...