меланома из родинки

The first researches devoted эпидемиологии РШМ, have appeared in a century. Rigoni-Stern in 1842 has published the data based on studying of the register of death in Verona with 1760 on 1830. It{he} has noticed, that РШМ much more often caused death of married women and widows and did not meet at virgins and монахинь. This circumstance has allowed the scientist to state a hypothesis about infectious origin РШМ. Known interest submit data, published F.Gagnon (1950), - at studying 13000 case records монахинь Montreal and Quebec РШМ has not been found out never. The author connected similar results with low frequency of inflammatory diseases шейки a uterus at монахинь. In review Mogaji (1973) it is shown, that гистологически confirmed плоскоклеточный РШМ at virgins represents an exclusive rarity, these data are confirmed with researches Kessler (1976) and Skoqg (1982). Results of the epidemiological researches concerning a role in occurrence РШМ of the early beginning of a sexual life, early first pregnancy, often change of sexual partners, and also the infectious diseases transmitted in the sexual way are published. Подробнее...

During tumoral transformation the key role is played with virus genes Е6 and Е7 which activity is supervised регуляторным by site URR. This site генома contains area of the virus promotor, a locus репликации, энхенсерные elements, активирующие the sequences necessary for репликации virus ДНК, sites of linkage for fiber Е2, cellular factors of a transcription, receptors of a progesterone and глюкокортикоидных hormones [16]. In регуляторной areas генома the promotor р97 (ВПЧ type 16), р105 (ВПЧ type 18), regulating экспрессию virus genes settles down; activity of the promotor is adjusted by virus and cellular fibers. Онкобелок Е6 plays a role коактиватора, cooperating with factors of a transcription and elements of the basic транскрипционного a complex. Подробнее...