лечение рака предстательной железы

To this time concern definition Melnick (1952), A.D.Timofeevskim (1961) with the help of электронно-microscopic technics{technical equipment} of constant presence вирусоподобных телец in папиллломах. Barrett (1954) has established the fact of transfer генитальных кондилом at гетеросексуальных the sexual relations, Dunn and Ogilvie (1968) have allocated virus particles from генитальных warts [4,9]. As the characteristic of cytologic changes in эпителии шейки a uterus, observable at папилломатозе, Aure (1949) described перинуклеарные changes in cells{cages} at research мазков with шейки a uterus. For the description of similar changes Koss, Durfee (1956) have entered into clinical practice the term " койлоцитотическая атипия " for which large cells{cages} with rather small гиперхромным a nucleus surrounded with transparent cytoplasm are characteristic. Authors for the first time have noted communication{connection} between койлоцитотической атипией. дисплазией and РШМ. Woodruff, Peterson (1958) and Pitkin, Kent (1963) have described histologic characteristics of classical forms папилломатозных кондилом; long time папилломатозные кондиломы were considered as unique morphological display папилломавирусной infections of sexual ways [9,10]. Подробнее...

Depth инвазии tumours, defeat of lymphatic vessels and units, параметральная and влагалищная инфильтрация do not depend from молекулярно-genetic a determinant of infection ВПЧ [14]. Кing (1989) has not found out communication{connection} between type ВПЧ revealed in a tumour and frequency of metastasises in регионарные лимфоузлы, Girardi (1992) observed more often defeat параметриев and лимфоузлов in cases, positive on ВПЧ type 16. Results of researches Sebbelov (1991), Kentner (1993), Ikenberg (1994) have not shown association between молекулярно-genetic determinants of infection ВПЧ and the forecast, in works Walker (1989) and Burnett (1992) is informed on much worse forecast in cases, positive on ВПЧ type 18 [цит. On 14]. However the majority of researches includes no more than 100 cases, thus definition of presence of virus sequences was made by a method of блот-hybridization on Саузерну, allowing to reveal fragments генома ВПЧ no more than in 75 % of cases РШМ [14]. Подробнее...