рентгендиагностика в онкологии
The direction of action of fiber Е6 (супрессорное or трансактивирующее) is defined{determined} by character, position and number of sites of linkage транскрипционных factors in promotors. The promotor р97 (ВПЧ type 16) can play a role in maintenance of a latent condition of a virus infection. With онкобелком Е6 ВПЧ types 16 and 18 7 cellular fibers cooperate at least, now from them 3 cellular fibers are identified: р53, Е6-АР, Е6-ВР. The gene р53 is associated both with the control of cellular growth, and with неопластической transformation; делеции or mutations in some cases transform р53 in active онкоген. Not all malignant tumours have mutations р53, the alternative mechanism инактивации р53 however is proved by linkage with онкобелком Е6 ВПЧ types 16 and 18, that results in loss of the control for пролиферацией cells{cages}. Cellular fiber Е6-АР (Е6 associated protein) in a complex with онкобелком Е6 participates in degradation р53, and also, probably, shortens the period полужизни and reduces a level р53 in ВПЧ-иммортализованных cells{cages}. Fiber Е6-ВР (E6-binding protein) cooperates with gene Е6 ВПЧ of types 16 and 18, that in result results in inhibition of process of a differentiation of cells{cages} and, probably, creates conditions for репликации virus ДНК. Подробнее...
The sizes of tumoral formations{educations} after циторедуктивной operations essentially influence results of the subsequent therapy and the forecast of the patient. So, average life expectancy of patients with the sizes of residual tumoral units less than 0,5 sm make 40 months, and at the sizes of 18 and 6 months of 0,5-2 and more 2 sm accordingly [2]. For this reason optimum executed циторедуктивной operation considers at what the maximal sizes of the staying tumoral formations{educations} do not exceed 2 see. In some centers under optimum циторедукцией accept the sizes of the staying tumoral formations{educations} less than 1 see. For achievement similar циторедукции the surgeon sometimes should carry out plural resections of a gut, a liver, a spleen, a bladder, a diaphragm, to use ultrasonic аспиратор and laser коагулятор for removal{distance} fine диссеминатов. Clearly, that циторедуктивные operations are considered technically complex{difficult} and demand high qualification of the surgeon specializing in онкогинекологии. Despite of all this, frequency of performance optimum циторедукции in conducting{leading} clinics of the world makes 23-54 %, and only separate authors achieve it at 75-90 % of patients. Подробнее...
