консультация дерматоонколога в институте онкологии
Регуляторная the area virus генома (upstream regulatory region, URR) settles down between the end of area of late genes and the beginning of area of early genes. Open frameworks of reading ORF генома a virus are divided{shared} on early (early, Е) and late (late, L) sites. The early fragment includes genes Е1-Е7 coding synthesis of fibers, responsible{crucial} for various functions in process репликации a virus and transformation of cells{cages}. Genes Е1 and Е2 are responsible{crucial} for репликацию a virus, and also participate in regulation of a transcription virus генома. The product of gene Е1 is responsible for maintenance персистенции virus генома in эписомальной to the form. Gene Е2 codes products which can as a trance - activate, and to suppress экспрессию early genes and энхенсерных sites URR. Трансактивирующий the factor is identified in precancer changes шейки a uterus, репрессирующий the factor in vivo is not identified [16]. Gene Е4 participates during maturing virus particles, genes Е5-Е7 possess трансформирующим potential. Genes Е6 and Е7 are always defined{determined} and экспрессируются in tumours шейки a uterus and received of tumours шейки a uterus cellular lines. The biological effect трансформирующего potential of genes Е6 and Е7 will be considered below. The late fragment генома will consist of genes L1 and L2, coding structural fibers вириона [5,21]. Подробнее...
In 1997 the works devoted to an oncological estimation of the given approach in reconstructive - plastic surgery dairy железы began to appear. So Carlson in 1997 has published materials of research [34], where compared frequency of development of local relapses and postoperative complications in groups of patients by which have been executed standard radical мастэктомия (188 operations, the average period of supervision 48,2 мес) and мастэктомия to preservation of a leather{skin} (327, the average period of supervision 37,5 мес) with one-stage reconstruction dairy железы with 1989 on 1994. Local relapses инвазивного a cancer in group стандарных мастэктомий have made 9,5 %, and in group мастэктомии with preservation of a leather{skin} - 4,8 %. Interventions were not required from 45 % of patients in the first group on opposite dairy iron while in the second group at 65 % of patients satisfactory symmetry after the first operation has been achieved. Also the percent{interest} некроза skin rags after мастэктомии was compared. In the first group it{he} has made 11,2 %, and in group мастэктомии with preservation of a leather{skin} of 10,7 %, i.e. essentially did not differ. Unfortunately, authors do not explain, to what decrease{reduction} in number of relapses almost twice in group where the theoretical risk of development of relapse should be higher can be connected. Подробнее...
