мед онкология

The direction of action of fiber Е6 (супрессорное or трансактивирующее) is defined{determined} by character, position and number of sites of linkage транскрипционных factors in promotors. The promotor р97 (ВПЧ type 16) can play a role in maintenance of a latent condition of a virus infection. With онкобелком Е6 ВПЧ types 16 and 18 7 cellular fibers cooperate at least, now from them 3 cellular fibers are identified: р53, Е6-АР, Е6-ВР. The gene р53 is associated both with the control of cellular growth, and with неопластической transformation; делеции or mutations in some cases transform р53 in active онкоген. Not all malignant tumours have mutations р53, the alternative mechanism инактивации р53 however is proved by linkage with онкобелком Е6 ВПЧ types 16 and 18, that results in loss of the control for пролиферацией cells{cages}. Cellular fiber Е6-АР (Е6 associated protein) in a complex with онкобелком Е6 participates in degradation р53, and also, probably, shortens the period полужизни and reduces a level р53 in ВПЧ-иммортализованных cells{cages}. Fiber Е6-ВР (E6-binding protein) cooperates with gene Е6 ВПЧ of types 16 and 18, that in result results in inhibition of process of a differentiation of cells{cages} and, probably, creates conditions for репликации virus ДНК. Подробнее...

One more interesting work on this theme has been issued in 1998 Slavin with colleagues [38]. Except for discussion of technical features of performance мастэктомии with preservation of a leather{skin} and one-stage reconstruction by a rag on the broadest muscle of a back with эндопротезированием, authors also had been lead{had been carried out} research of presence эпителия внедольковых channels in border of a resection of a leather{skin} dairy железы on distance of 5 mm from ареолы. In one case from 144 биопсий at 32 patients not was cells{cages} эпителия channels are found out. The percent{interest} of local relapses has made 2 % with the average period of supervision of 45 months. Подробнее...