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The data on influence of long steroid contraception on frequency дисплазии and a cancer шейки a uterus разноречивы. Insignificant increase in frequency дисплазии and преинвазивного РШМ at the women using steroid contraceptives, have noted Andolsek with соавт. (1983), Piper (1985.) Svan and Brown (1981), Vassey with соавт. (1983) have defined{determined} relative risk РШМ equal 1,5 and 2,5 accordingly, in other researches it is not marked correlations between application of hormonal contraceptives and РШМ [3]. Experts the CART (Geneva, 1985) Came to a conclusion, that the treatment of the data on use of steroid contraceptives is inconvenient as because of the big number of preparations and absence of the authentic cytologic control over a condition эпителия шейки a uterus prior to the beginning and during application of steroid contraceptives, and owing to interrelation of frequency of application of contraceptives and sexual activity. Now there are convincing data on raised{increased} risk РШМ at smoking щенщин. Hellberg with соавт. (1983), Greenberg with соавт. (1986), Winkelstein (1985), Brinton (1986) mark association of smoking with the early beginning of a sexual life and often change of sexual partners, Hoffman with соавт. (1985), Sasson with соавт. (1985) suppose to a - cancerogenic role contained in a tobacco smoke of nicotine and котинина [4]. Подробнее...

1491 patient with a cancer has taken part in research BCRIG01 dairy железы with positive axillary лимфоузлами; middle age has made 49 years, 62 % of patients had from 1 up to 3 лимфоузлов, at 69 % of a tumour were рецепторопозитивными on РЭ and РП, at 20 % - positive on HER2/neu. All patients having positive РЭ and РП, received also тамоксифен in a doze of 20 mg / ЯТФ. Within 5 years. The median of time of supervision at the moment of the analysis of results has made 33 (0-49) months. Подробнее...