московский научно исследовательский институт онкологии

Known types папилломавирусов the person are similar on the genetic structure. The genetic material of a virus is submitted by ring two-chained molecule ДНК in length about 8000 pairs the bases that corresponds{meets} to weight about D.Odna's 5 million from strings ДНК contains 9 open frameworks of reading (open reading frames, ORF) which potentially code up to 10 proteins, and регуляторный a site генома (upstream regulatory region, URR). Other string ДНК not coding. Подробнее...

During many years was considered, that usual, flat (ювенильные) and генитальные warts are caused by one type папилломавируса, and distinctions in clinical current are caused by distinctions in localization. Sights at a pathology кондилом шейки a uterus have been considerably reconsidered after Meisels, Fortin (1976), Purola, Savia (1976) have described генитальные flat and inverted (эндофитные) кондиломы, having defined{determined} their basic difference from кондилом other localizations, and postulated цитоморфологические attributes папилломавирусной infections: коилоцитоз or баллонирование the cells{cages}, described increased, гиперхромными the nucleus surrounded with a precise zone of light cytoplasm. Later with the help электронно-microscopic, иммуногистохимических and ДНК-гибридизационных researches it has been confirmed them папилломавирусная этиология [9,20]. Подробнее...