детская онкология

The decision on a choice of preparations for chemotherapy of the second line should be based, first of all, on definition of sensitivity of a tumour to derivatives of platinum after chemotherapy of the first line. The interval between the termination{ending} of therapy of the first line and progressing of disease more than 6 months testifies to high sensitivity of a tumour derivatives of platinum. Such patient for treatment of relapses should be appointed a combination of derivatives of platinum and new preparations from among that are used for carrying out of the second line of chemotherapy. At separate patients with duration of remission more than 12 months probably carrying out of chemotherapy of the second line by the same combination which was used at a stage of an induction. Frequency of objective effect at use of a combination of derivatives of platinum (is $more often карбоплатина in view of his{its} smaller toxicity) and new preparations makes 30-50 % at average life expectancy of sick 12-14 months. Подробнее...

The private residence costs{stands} research ICON-3 in which 2039 patients Ic-IV with stages of a cancer яичников have taken part. In control group patients received карбоплатин in doze AUC> 5 or combination САР (500/50/50 mg / m2), in compared group - a combination цисплатина and паклитаксела (75/175 mg / m2). Treatment was carried out{was spent} each 3 weeks in volume of 6 rates. The preliminary data testify that time before progressing and general life expectancy was identical irrespective of used chemotherapy. Sick (57 %) in group карбоплатина and CAP received the majority таксаны as chemotherapy of the second line that explains rather good remote results. Подробнее...